Extralymphoid CD8 T Cells Resident in Tissue from Simian Immunodeficiency Virus SIVmac239 nef-Vaccinated Macaques Suppress SIVmac239 Replication Ex Vivo
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چکیده
Published Ahead of Print 20 January 2010. 2010, 84(7):3362. DOI: 10.1128/JVI.02028-09. J. Virol. A. Price, Shelby L. O'Connor and David H. O'Connor Emma Gostick, Thomas C. Friedrich, Karl W. Broman, David Melisa L. Budde, Caitlin E. Macnair, Madelyn K. Weiker, Justin M. Greene, Jennifer J. Lhost, Benjamin J. Burwitz, Ex Vivo Suppress SIVmac239 Replication nef-Vaccinated Macaques ∆ Virus SIVmac239 Tissue from Simian Immunodeficiency T Cells Resident in + Extralymphoid CD8
منابع مشابه
Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.
Live-attenuated vaccination with simian immunodeficiency virus (SIV) SIVmac239Deltanef is the most successful vaccine product tested to date in macaques. However, the mechanisms that explain the efficacy of this vaccine remain largely unknown. We utilized an ex vivo viral suppression assay to assess the quality of the immune response in SIVmac239Deltanef-immunized animals. Using major histocomp...
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